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Mitchell G. Patton

13548 Posts
Therapeutic vaccines: the concept gaining ground in oncology

Oncology Innovations: Therapeutic Vaccines Take Center Stage

Therapeutic cancer vaccines represent a shift from prevention to active treatment: instead of preventing infection or disease onset, they aim to train the patient’s immune system to recognize and destroy existing tumor cells. Over the past decade, advances in immunology, genomic sequencing, and delivery technologies have moved therapeutic vaccines from concept and small trials toward real-world approvals and large randomized studies. This article explains the core concepts, describes leading modalities and examples, examines clinical data and challenges, and highlights where the field is likely to go next.What is a therapeutic cancer vaccine?A therapeutic cancer vaccine stimulates the immune system to…
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How do companies measure productivity gains from AI copilots at scale?

Benchmarking AI Copilot Productivity at Scale

Productivity gains from AI copilots are not always visible through traditional metrics like hours worked or output volume. AI copilots assist knowledge workers by drafting content, writing code, analyzing data, and automating routine decisions. At scale, companies must adopt a multi-dimensional approach to measurement that captures efficiency, quality, speed, and business impact while accounting for adoption maturity and organizational change.Defining What “Productivity Gain” Means for the BusinessBefore any measurement starts, companies first agree on how productivity should be understood in their specific setting. For a software company, this might involve accelerating release timelines and reducing defects, while for a sales…
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Why are secondaries becoming a mainstream private market strategy?

The Rise of Secondaries: A Mainstream Private Market Tactic

Secondaries refer to transactions in which investors buy and sell existing interests in private market funds or assets, rather than committing capital to new, primary investments. Historically, these transactions were niche, often driven by distressed sellers seeking liquidity. Today, secondaries have evolved into a core private market strategy, spanning private equity, private credit, real assets, and venture capital.The growth of secondaries reflects structural changes in how private markets operate, how investors manage portfolios, and how capital seeks efficiency in an uncertain macroeconomic environment.The Structural Forces Driving Mainstream AdoptionSeveral long-term forces explain why secondaries have moved from the margins to the…
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Value vs. Growth vs. Quality: Investor Styles Across Cycles

Value vs. Growth vs. Quality: Investor Styles Across Cycles

Investors often categorize equities into value, growth, and quality styles to structure portfolios and expectations. Comparing these styles over a full market cycle—from expansion to peak, contraction, and recovery—helps investors understand why leadership rotates and how diversification can improve outcomes. A full cycle typically spans several years and includes changing economic growth, inflation, interest rates, and risk appetite.An Overview of the Three StylesValue: Stocks trading at relatively low prices compared with fundamentals such as earnings, book value, or cash flow. Common metrics include price-to-earnings and price-to-book ratios.Growth: Companies expected to grow revenues and earnings faster than the market average, often…
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